Patient Zero is a 2018 science fiction horror film directed by Stefan Ruzowitzky and written by Mike Le. The film stars Matt Smith, Natalie Dormer, John Bradley, Stanley Tucci, Agyness Deyn, and Clive Standen. The plot involves a group of survivors who set out to find an antidote for a highly contagious virus that turns the infected into a ravenous but highly intelligent new species.